Identification of transmembrane region and orientation of aquaglyceroporin of Plasmodium falciparum.
نویسنده
چکیده
Aquaglyceroporin is a subclass of aquaporin water channels. This protein is also a focused potential drug target for falciparum malaria. However, the knowledge about the structure of this protein is limited. In this communication, the author performed a study to determine the transmembrane region and orientation of aquaglyceroporin of Plasmodium falciparum . According to this study, six transmembrane regions of aquaglyceroporin of P. falciparum can be identified. These regions can be the focused target for future drug development.
منابع مشابه
Glycerol inhibits water permeation through Plasmodium falciparum aquaglyceroporin.
Plasmodium falciparum aquaglyceroporin (PfAQP) is a multifunctional membrane protein in the plasma membrane of P. falciparum, the parasite that causes the most severe form of malaria. The current literature has established the science of PfAQP's structure, functions, and hydrogen-bonding interactions but left unanswered the following fundamental question: does glycerol modulate water permeation...
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The aquaglyceroporin from Plasmodium falciparum (PfAQP) is a potential drug target for the treatment of malaria. It efficiently conducts water and other small solutes, and is proposed to intervene in several crucial physiological processes during the parasitic life cycle. Despite the wealth of experimental data available, a dynamical and energetic description at the single-molecule level of the...
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The malaria parasite Plasmodium falciparum faces drastic osmotic changes during kidney passages and is engaged in the massive biosynthesis of glycerolipids during its development in the blood-stage. We identified a single aquaglyceroporin (PfAQP) in the nearly finished genome of P. falciparum with highest similarity to the Escherichia coli glycerol facilitator (50.4%), but both canonical Asn-Pr...
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عنوان ژورنال:
- Indian journal of medical microbiology
دوره 26 3 شماره
صفحات -
تاریخ انتشار 2008